Wide infrabony defects: Stable results with Geistlich Bio-Oss^® Collagen

For the first time a 5-year prospective study from Belgium has investigated the clinical and radiographic outcome of regenerative periodontal therapy (RPT) using minimally invasive surgery and Geistlich Bio-Oss® Collagen to treat at least one interdental infrabony defect.¹

RPT has been proposed as a viable treatment concept for infrabony defects.² Histological studies have demonstrated the regeneration potential for Guided Tissue Regeneration (GTR),³ allograft,⁴ xenograft,⁵ and enamel matrix derivative.⁶ Since a prerequisite for broad application of RPT is procedural simplicity, EMD may be considered more favorably than GTR. However, EMD may not be ideal for treating wide defects, especially those with a non-supportive anatomy, which could instead benefit from a treatment with Geistlich Bio-Oss® Collagen.
 

Select highly compliant and plaque-free patients

Before surgery, mean probing depth (PD) was 7.8 mm, mean clinical attachment level (CAL) was 10.0 mm, and mean defect depth was 5.2 mm. A total of 71 patients could be evaluated at five years. Mean PD reduction was 3.3 mm, mean CAL gain was 3.0 mm, and mean radiographic bone gain was 57%. No significant difference was observed in any of these parameters between one and five years, which demonstrates stable results.

RPT succeeded in 76% of the cases (≥ 1 mm CAL gain) and regression analyses showed superior outcomes in highly compliant and plaque-free patients. The predictability of RPT can therefore be improved by very stringent case selection: only patients with perfect oral hygiene and excellent compliance should be considered.
 

References

1. De Bruyckere T, et al.: Clin Oral Investig. 2018 Apr;22(3):1235-1242 (clinical study).
2. Papapanou PN, Wennström JL: J Clin Periodontol. 1991 May;18(5):317-22 (clinical study).
3. Gottlow J, et al.: J Clin Periodontol. 1986 Jul;13(6):604-16 (clinical study).
4. Bowers GM, et al.: J Periodontol. 1989 Dec;60(12):683-93 (clinical study).
5. Nevins ML, et al.: Int J Periodontics Restorative Dent. 2005 Aug;25(4):365-73 (clinical study).
6. Yukna RA, Mellonig JT: J Periodontol. 2000 May;71(5):752-9 (clinical study).

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